Galactosidase Alpha (GLa)

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GALA; GL-A; Alpha-D-Galactoside Galactohydrolase; Alpha-D-Galactosidase A; Melibiase; Agalsidase

Galactosidase Alpha (GLa)

Alpha-galactosidase is a glycoside hydrolase enzyme that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. It is encoded by the GLA gene. This enzyme is a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. It predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry's disease, a rare lysosomal storage disorder and sphingolipidosis that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. Genzyme produces synthetic agalsidase beta under the brand name Fabrazyme for treatment of Fabry's disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA183Hu01 Recombinant Galactosidase Alpha (GLa) Positive Control; Immunogen; SDS-PAGE; WB.
RPA183Hu02 Recombinant Galactosidase Alpha (GLa) Positive Control; Immunogen; SDS-PAGE; WB.
RPA183Hu03 Recombinant Galactosidase Alpha (GLa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA183Hu01 Polyclonal Antibody to Galactosidase Alpha (GLa) WB; IHC; ICC; IP.
PAA183Hu03 Polyclonal Antibody to Galactosidase Alpha (GLa) WB; IHC; ICC; IP.
PAA183Hu02 Polyclonal Antibody to Galactosidase Alpha (GLa) WB; IHC; ICC; IP.
LAA183Hu71 Biotin-Linked Polyclonal Antibody to Galactosidase Alpha (GLa) WB; IHC; ICC.
LAA183Hu81 FITC-Linked Polyclonal Antibody to Galactosidase Alpha (GLa) WB; IHC; ICC; IF.
MAA183Hu21 Monoclonal Antibody to Galactosidase Alpha (GLa) WB; IHC; ICC; IP.
MAA183Hu22 Monoclonal Antibody to Galactosidase Alpha (GLa) WB; IHC; ICC; IP.
LAA183Hu72 Biotin-Linked Monoclonal Antibody to Galactosidase Alpha (GLa) WB; IHC; ICC.
LAA183Hu82 FITC-Linked Monoclonal Antibody to Galactosidase Alpha (GLa) WB; IHC; ICC; IF.
Assay Kits SEA183Hu ELISA Kit for Galactosidase Alpha (GLa) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA183Hu CLIA Kit for Galactosidase Alpha (GLa) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA183Mu01 Recombinant Galactosidase Alpha (GLa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA183Mu01 Polyclonal Antibody to Galactosidase Alpha (GLa) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Galactosidase Alpha (GLa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Galactosidase Alpha (GLa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Galactosidase Alpha (GLa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Galactosidase Alpha (GLa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Galactosidase Alpha (GLa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Galactosidase Alpha (GLa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Galactosidase Alpha (GLa) ELISA Kit Customized Service Offer
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  47. "Natural history of Fabry renal disease: influence of alpha-galactosidase A activity and genetic mutations on clinical course."Medicine (Baltimore) 81:122-138(2002) [PubMed] [Europe PMC] [Abstract]
  48. "Two novel mutations in the alpha-galactosidase A gene in Chinese patients with Fabry disease."Clin. Genet. 63:205-209(2003) [PubMed] [Europe PMC] [Abstract]
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