Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4)

[Edit]

SCCA2; PI11; SPB4; Leupin; Serpin Peptidase Inhibitor,Clade B,Member 4; Peptidase Inhibitor 11

Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4)

Squamous cell carcinoma antigen (SCCA), a member of the serine protease inhibitor (serpin) family, is a subfraction of the tumor associated antigen TA-4, is a glycoprotein, with a molecular weight between 42 to 48 kDa. SCCA2 is a serological marker for squamous cell carcinomas (SCC). Elevated serum levels are correlated with the clinical stage of the disease.Schneider et al. demonstrated that 18q21.3 contains a cluster of serine proteinase inhibitors, or 'serpins,' including a tandem duplication of the squamous cell carcinoma antigen (SCCA) gene and 2 other members of the ovalbumin family of serine proteinase inhibitors, plasminogen activator inhibitor type 2 and maspin (protease inhibitor-5). Schneider et al. presented evidence that the neutral and acidic forms of SCCA are encoded by SCCA1 and SCCA2, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA159Hu01 Recombinant Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA159Hu03 Recombinant Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA159Hu01 Polyclonal Antibody to Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) WB; IHC; ICC; IP.
MAA159Hu22 Monoclonal Antibody to Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) WB; IHC; ICC; IP.
LAA159Hu71 Biotin-Linked Polyclonal Antibody to Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) WB; IHC; ICC.
LAA159Hu81 FITC-Linked Polyclonal Antibody to Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) WB; IHC; ICC; IF.
PAA159Hu03 Polyclonal Antibody to Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) WB; IHC; ICC; IP.
Assay Kits SEA159Hu ELISA Kit for Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA159Mu01 Recombinant Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA159Mu02 Recombinant Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA159Mu01 Polyclonal Antibody to Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) WB; IHC; ICC; IP.
LAA159Mu71 Biotin-Linked Polyclonal Antibody to Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) WB; IHC; ICC.
PAA159Mu02 Polyclonal Antibody to Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) WB; IHC; ICC; IP.
Assay Kits SEA159Mu ELISA Kit for Serpin Peptidase Inhibitor,Clade B,Member 4 (SERPINB4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification of a novel human serpin gene; cloning sequencing and expression of leupin."FEBS Lett. 373:61-65(1995) [PubMed] [Europe PMC] [Abstract]
  2. "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene."Proc. Natl. Acad. Sci. U.S.A. 92:3147-3151(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter."Biochim. Biophys. Acta 1518:124-131(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]