Vascular Endothelial Growth Factor D (VEGFD)

[Edit]

FIGF; VEGF-D; C-Fos Induced Growth Factor

Vascular Endothelial Growth Factor D (VEGFD)

VEGFD was most closely related to VEGFC by virtue of the presence of N- and C-terminal extensions that were not found in other VEGF family members. In adult human tissues, VEGFD mRNA was most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGFD receptor specificity revealed that VEGFD is a ligand for both VEGF receptors: VEGFR2 (FLK1) and VEGFR3 (FLT4); furthermore, VEGFD activates these receptors. However, VEGFD did not bind to VEGFR1. Expression of a truncated derivative of VEGFD demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGFC.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA146Hu01 Recombinant Vascular Endothelial Growth Factor D (VEGFD) Positive Control; Immunogen; SDS-PAGE; WB.
EPA146Hu61 Eukaryotic Vascular Endothelial Growth Factor D (VEGFD) Positive Control; Immunogen; SDS-PAGE; WB.
APA146Hu01 Active Vascular Endothelial Growth Factor D (VEGFD) Cell culture; Activity Assays.
Antibodies PAA146Hu01 Polyclonal Antibody to Vascular Endothelial Growth Factor D (VEGFD) WB; IHC; ICC; IP.
MAA146Hu22 Monoclonal Antibody to Vascular Endothelial Growth Factor D (VEGFD) WB; IHC; ICC; IP.
LAA146Hu71 Biotin-Linked Polyclonal Antibody to Vascular Endothelial Growth Factor D (VEGFD) WB; IHC; ICC.
Assay Kits SEA146Hu ELISA Kit for Vascular Endothelial Growth Factor D (VEGFD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA146Mu01 Recombinant Vascular Endothelial Growth Factor D (VEGFD) Positive Control; Immunogen; SDS-PAGE; WB.
RPA146Mu02 Recombinant Vascular Endothelial Growth Factor D (VEGFD) Positive Control; Immunogen; SDS-PAGE; WB.
EPA146Mu61 Eukaryotic Vascular Endothelial Growth Factor D (VEGFD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA146Mu01 Polyclonal Antibody to Vascular Endothelial Growth Factor D (VEGFD) WB; IHC; ICC; IP.
PAA146Mu02 Polyclonal Antibody to Vascular Endothelial Growth Factor D (VEGFD) WB; IHC; ICC; IP.
Assay Kits SEA146Mu ELISA Kit for Vascular Endothelial Growth Factor D (VEGFD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA146Ra01 Recombinant Vascular Endothelial Growth Factor D (VEGFD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA146Ra01 Polyclonal Antibody to Vascular Endothelial Growth Factor D (VEGFD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Vascular Endothelial Growth Factor D (VEGFD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vascular Endothelial Growth Factor D (VEGFD) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA146Bo01 Recombinant Vascular Endothelial Growth Factor D (VEGFD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA146Bo01 Polyclonal Antibody to Vascular Endothelial Growth Factor D (VEGFD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Vascular Endothelial Growth Factor D (VEGFD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vascular Endothelial Growth Factor D (VEGFD) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a novel vascular endothelial growth factor, VEGF-D."Genomics 42:483-488(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes."Genomics 47:207-216(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)."Proc. Natl. Acad. Sci. U.S.A. 95:548-553(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers."J. Biol. Chem. 274:32127-32136(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Structural determinants of vascular endothelial growth factor-D - receptor binding and specificity."Blood 117:1507-1515(2011) [PubMed] [Europe PMC] [Abstract]