Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL)

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CD253; TNFSF10; APO2L; Apo2-L; TL2; TRAIL; Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand

Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL)

TRAIL is a recently identified member of the TNF gene superfamily. Five different receptors have been identified for TRAIL. Two receptors, DR4 and DR5, are transmembrane proteins containing death domain similar to FAS and other TNF family receptors. Two other receptors, DcR1 and DcR2, act like decoy proteins for TRAIL binding because they lack the death domain. TRAIL can also bind, though weakly, to osteoprotegrin (OPG), a soluble receptor, which plays a role in osteoclastogenesis. TRAIL induces apoptosis in various tumor cell lines, whereas most primary cells seem to be resistant. TRAIL-mediated apoptosis occurs following its binding to DR4 or DR5 receptors. The mechanism of apoptosis involves activation of caspase-8 and subsequent activation of effector caspases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA139Hu01 Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Positive Control; Immunogen; SDS-PAGE; WB.
APA139Hu01 Active Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Cell culture; Activity Assays.
Antibodies PAA139Hu01 Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC; IP.
MAA139Hu22 Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC; IP.
LAA139Hu71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC.
LAA139Hu81 FITC-Linked Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC; IF.
LAA139Hu72 Biotin-Linked Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC.
LAA139Hu82 FITC-Linked Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC; IF.
Assay Kits SEA139Hu ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA139Hu CLIA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA139Mu01 Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Positive Control; Immunogen; SDS-PAGE; WB.
RPA139Mu02 Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA139Mu01 Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC; IP.
LAA139Mu71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC.
PAA139Mu02 Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC; IP.
Assay Kits SEA139Mu ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA139Ra01 Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA139Ra01 Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC; IP.
MAA139Ra21 Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC; IP.
Assay Kits SEA139Ra ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA139Ca01 Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA139Ca01 Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC; IP.
MAA139Ca21 Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) WB; IHC; ICC; IP.
Assay Kits SEA139Ca ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) Enzyme-linked immunosorbent assay for Antigen Detection.
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