Tissue Inhibitors Of Metalloproteinase 3 (TIMP3)

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SFD; TIMP Metallopeptidase Inhibitor 3; Metallopeptidase Inhibitor 3; Sorsby Fundus Dystrophy; Pseudoinflammatory

Tissue Inhibitors Of Metalloproteinase 3 (TIMP3)

TIMP3,  The cDNAs contained a 591-bp open reading frame encoding 9 amino acid residues of the signal peptide and 188 residues of the mature TIMP3 polypeptide. Both the nucleotide sequence and the deduced translation product of the TIMP3 cDNA had a high degree of similarity to the TIMP1 and TIMP2 gene products, including 12 conserved cysteinyl residues at the same relative positions. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. Wilde et al. (1994) cloned and sequenced TIMP3 from phorbol ester-differentiated cells stimulated with bacterial lipopolysaccharide. The open reading frame encoded a 211-amino acid precursor, including a 23-residue secretion signal. The mature polypeptide had a calculated molecular weight of 21.6 kD.

 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA129Hu01 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
APA129Hu01 Active Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Cell culture; Activity Assays.
Antibodies PAA129Hu01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
MAA129Hu22 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
Assay Kits SEA129Hu ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA129Hu CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA129Mu01 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA129Mu02 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA129Mu01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
LAA129Mu71 Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC.
PAA129Mu02 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
Assay Kits SEA129Mu ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA129Mu CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA129Ra01 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA129Ra01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
MAA129Ra21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
Assay Kits SEA129Ra ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA129Ra CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA129Rb01 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA129Rb51 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
MAA129Rb21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
Assay Kits SEA129Rb ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA129Rb CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA129Si01 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA129Si01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
MAA129Si21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
Assay Kits SEA129Si ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA129Si CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA129Po01 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA129Po01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
MAA129Po21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
Assay Kits SEA129Po ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA129Po CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA129Bo01 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA129Bo01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
MAA129Bo21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
Assay Kits SEA129Bo ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA129Bo CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA129Cp01 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA129Cp01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
MAA129Cp21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
Assay Kits SEA129Cp ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA129Cp CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA129Eq01 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA129Eq01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
MAA129Eq21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
Assay Kits SEA129Eq ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA129Eq CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA129Ga01 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA129Ga01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
MAA129Ga21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
Assay Kits SEA129Ga ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA129Ga CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA129Fi01 Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA129Fi01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) ELISA Kit Customized Service Offer
  1. "Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family."Cancer Res. 54:2091-2094(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of human tissue inhibitor of metalloproteinases-3."DNA Cell Biol. 13:711-718(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family."Gene 141:293-297(1994) [PubMed] [Europe PMC] [Abstract]
  4. "A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence."J. Biol. Chem. 269:18953-18960(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic organization of the human tissue inhibitor of metalloproteinases-3 (TIMP3)."Genome Res. 5:483-487(1995) [PubMed] [Europe PMC] [Abstract]
  6. "TIMP-3 is expressed in the human retinal pigment epithelium."Biochem. Biophys. Res. Commun. 226:467-474(1996) [PubMed] [Europe PMC] [Abstract]
  7. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22."Genomics 19:86-90(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix."Matrix Biol. 14:479-488(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Cloning and partial structure of the gene encoding human tissue inhibitor of metalloproteinases-3."Gene 170:287-288(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations."J. Biol. Chem. 279:30469-30473(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex."J. Mol. Biol. 381:1307-1319(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy."Nat. Genet. 8:352-356(1994) [PubMed] [Europe PMC] [Abstract]
  17. "A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features."Hum. Mol. Genet. 4:2415-2416(1995) [PubMed] [Europe PMC] [Abstract]
  18. "Night blindness in Sorsby's fundus dystrophy reversed by vitamin A."Nat. Genet. 11:27-32(1995) [PubMed] [Europe PMC] [Abstract]
  19. "A second independent Tyr168Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy."J. Med. Genet. 33:233-236(1996) [PubMed] [Europe PMC] [Abstract]
  20. "Autosomal recessive Sorsby fundus dystrophy revisited: molecular evidence for dominant inheritance."Am. J. Hum. Genet. 60:57-62(1997) [PubMed] [Europe PMC] [Abstract]