Tissue Inhibitors Of Metalloproteinase 2 (TIMP2)

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CSC-21K; TIMP Metallopeptidase Inhibitor 2

Tissue Inhibitors Of Metalloproteinase 2 (TIMP2)

TIMP2, is  a member of the TIMP family. The proteins  are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. In melanocytic cells TIMP2 gene expression may be regulated by MITF.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA128Hu01 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
EPA128Hu61 Eukaryotic Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
APA128Hu01 Active Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Cell culture; Activity Assays.
RPA128Hu02 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA128Hu03 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
APA128Hu61 Active Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Cell culture; Activity Assays.
Antibodies PAA128Hu01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
MAA128Hu22 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
LAA128Hu71 Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC.
PAA128Hu06 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
Assay Kits SEA128Hu ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA128Mu01 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA128Mu02 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA128Mu01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
PAA128Mu02 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
Assay Kits SEA128Mu ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA128Ra01 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA128Ra01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
LAA128Ra71 Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC.
LAA128Ra81 FITC-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IF.
MAA128Ra21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
Assay Kits SEA128Ra ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA128Gu01 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA128Gu01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA128Rb01 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA128Rb51 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA128Ca01 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA128Ca01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
LAA128Ca71 Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA128Po01 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA128Po01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
MAA128Po21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
Assay Kits SEA128Po ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA128Bo01 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA128Bo01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
MAA128Bo21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
Assay Kits SEA128Bo ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA128Eq01 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA128Eq01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
LAA128Eq71 Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC.
MAA128Eq21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
Assay Kits SEA128Eq ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA128Ga01 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA128Ga01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) ELISA Kit Customized Service Offer

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA128Fi01 Recombinant Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA128Fi01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) ELISA Kit Customized Service Offer
  1. "Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues."J. Biol. Chem. 265:13933-13938(1990) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases."Proc. Natl. Acad. Sci. U.S.A. 87:2800-2804(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene."J. Biol. Chem. 271:25498-25505(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family."J. Biol. Chem. 264:17374-17378(1989) [PubMed] [Europe PMC] [Abstract]
  6. "TIMP-2: identification and characterization of a new member of the metalloproteinase inhibitor family."Matrix Suppl. 1:299-306(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2."Proc. Natl. Acad. Sci. U.S.A. 86:8207-8211(1989) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid."FEBS Lett. 296:16-20(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2)."Gene 139:185-191(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site."J. Biol. Chem. 266:17972-17977(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity."J. Cancer Res. Clin. Oncol. 127:653-658(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family."Biochemistry 33:11745-11759(1994) [PubMed] [Europe PMC] [Abstract]
  13. "High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3."J. Biol. Chem. 273:21736-21743(1998) [PubMed] [Europe PMC] [Abstract]
  14. "Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1-A resolution."J. Mol. Biol. 284:1133-1140(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2."Proc. Natl. Acad. Sci. U.S.A. 99:7414-7419(2002) [PubMed] [Europe PMC] [Abstract]