Transforming Growth Factor Alpha (TGFa)

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ETGF; TGF-A; Protransforming Growth Factor alpha; EGF-Like TGF

Transforming Growth Factor Alpha (TGFa)

Transforming growth factor (TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ.TGFα is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects . TGFα stimulates neural cell proliferation in the adult injured brain.TGFα was cited in the 2001 NIH Stem Cell report to the U.S. Congress as promising evidence for the ability of adult stem cells to restore function in neurodegenerative disorders.

TGF-alpha shows about 40% sequence homology with epidermal growth factor (EGF) and competes with EGF for binding to the EGF receptor, stimulating its phosphorylation and producing a mitogenic response.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA123Hu01 Recombinant Transforming Growth Factor Alpha (TGFa) Positive Control; Immunogen; SDS-PAGE; WB.
APA123Hu01 Active Transforming Growth Factor Alpha (TGFa) Cell culture; Activity Assays.
RPA123Hu02 Recombinant Transforming Growth Factor Alpha (TGFa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA123Hu01 Polyclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
MAA123Hu22 Monoclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
LAA123Hu71 Biotin-Linked Polyclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC.
MAA123Hu21 Monoclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB,IHC
MAA123Hu23 Monoclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
MAA123Hu24 Monoclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
Assay Kits SEA123Hu ELISA Kit for Transforming Growth Factor Alpha (TGFa) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA123Hu CLIA Kit for Transforming Growth Factor Alpha (TGFa) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA123Mu01 Recombinant Transforming Growth Factor Alpha (TGFa) Positive Control; Immunogen; SDS-PAGE; WB.
RPA123Mu02 Recombinant Transforming Growth Factor Alpha (TGFa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA123Mu01 Polyclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
PAA123Mu02 Polyclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
Assay Kits SEA123Mu ELISA Kit for Transforming Growth Factor Alpha (TGFa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA123Ra01 Recombinant Transforming Growth Factor Alpha (TGFa) Positive Control; Immunogen; SDS-PAGE; WB.
RPA123Ra02 Recombinant Transforming Growth Factor Alpha (TGFa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA123Ra01 Polyclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
MAA123Ra21 Monoclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
Assay Kits SEA123Ra ELISA Kit for Transforming Growth Factor Alpha (TGFa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA123Rb01 Recombinant Transforming Growth Factor Alpha (TGFa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA123Rb51 Polyclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Alpha (TGFa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Alpha (TGFa) ELISA Kit Customized Service Offer

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA123Si01 Recombinant Transforming Growth Factor Alpha (TGFa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA123Si01 Polyclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Alpha (TGFa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Alpha (TGFa) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA123Po01 Recombinant Transforming Growth Factor Alpha (TGFa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA123Po01 Polyclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Alpha (TGFa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Alpha (TGFa) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transforming Growth Factor Alpha (TGFa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transforming Growth Factor Alpha (TGFa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transforming Growth Factor Alpha (TGFa) Polyclonal Antibody Customized Service Offer
Assay Kits SEA123Bo ELISA Kit for Transforming Growth Factor Alpha (TGFa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA123Cp01 Recombinant Transforming Growth Factor Alpha (TGFa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA123Cp01 Polyclonal Antibody to Transforming Growth Factor Alpha (TGFa) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Alpha (TGFa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Alpha (TGFa) ELISA Kit Customized Service Offer
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  2. "A novel low molecular weight ribonucleic acid (RNA) related to transforming growth factor alpha messenger RNA."Mol. Endocrinol. 2:1056-1063(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Human transforming growth factor alpha: sequence analysis of the 4.5-kb and 1.6-kb mRNA species."Gene 132:291-296(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions."Am. J. Hum. Genet. 53:168-175(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate only."Genomics 61:237-242(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Human keratinocytes and tumor-derived cell lines express alternatively spliced forms of transforming growth factor-alpha mRNA, encoding precursors lacking carboxyl-terminal valine residues."Oncogene 18:5554-5562(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence."Mol. Cell. Biol. 8:5549-5554(1988) [PubMed] [Europe PMC] [Abstract]
  11. "TGFA: exon-intron structure and evaluation as a candidate gene for Alstrom syndrome."Clin. Genet. 55:61-62(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of disulfide bond position in proteins and sequence analysis of cystine-bridged peptides by tandem mass spectrometry."Anal. Biochem. 201:216-226(1992) [PubMed] [Europe PMC] [Abstract]
  13. "Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association."J. Biol. Chem. 271:28502-28508(1996) [PubMed] [Europe PMC] [Abstract]
  14. "A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface."Mol. Cell 3:423-433(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells."J. Cell Sci. 120:2454-2466(2007) [PubMed] [Europe PMC] [Abstract]
  16. "EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation."Proc. Natl. Acad. Sci. U.S.A. 105:13433-13438(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structures of human transforming growth factor alpha derived from 1H NMR data."Biochemistry 29:7805-7813(1990) [PubMed] [Europe PMC] [Abstract]
  18. "The solution structure of human transforming growth factor alpha."Eur. J. Biochem. 198:555-562(1991) [PubMed] [Europe PMC] [Abstract]
  19. "Solution structure of human type-alpha transforming growth factor determined by heteronuclear NMR spectroscopy and refined by energy minimization with restraints."Biochemistry 32:7334-7353(1993) [PubMed] [Europe PMC] [Abstract]