Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES)

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CCL5; SCYA5; SISd; EoCP; Chemokine C-C-Motif Ligand 5; Eosinophil Chemotactic Cytokine; T-cell Specific Protein p288; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 5

Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES)

Regulated on activation in normal T cell expressed and secreted(RANTES) was identified in 1988, as a result of a subtractive hybridization screen for mRNA expressed by T cells, but not by B cells. In addition to T cells, RANTES is also produced by epithelial cells, monocytes, fibroblasts, and mesanglial cells. Platelets and eosinophils release RANTES from intracellular storage granules upon activation. Several high affinity receptors for RANTES have been described, including CCR1, CCR3, CCR5, and cytomegalovirus receptor US28. RANTES also binds to the erythrocyte Duffy antigen receptor (DARC) with low affinity. RANTES regulates the trafficking of cells expressing these receptors, including T cells, eosinophils, basophils, monocytes, macrophages, microglia, NK cells, dendritic cells, mast cells, and neurons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA116Hu01 Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Positive Control; Immunogen; SDS-PAGE; WB.
APA116Hu01 Active Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Cell culture; Activity Assays.
Antibodies PAA116Hu01 Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
MAA116Hu22 Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
LAA116Hu71 Biotin-Linked Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC.
Assay Kits SEA116Hu ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA116Hu CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA116Mu01 Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Positive Control; Immunogen; SDS-PAGE; WB.
RPA116Mu02 Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA116Mu01 Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
LAA116Mu71 Biotin-Linked Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC.
PAA116Mu02 Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
Assay Kits SEA116Mu ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA116Mu CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA116Ra01 Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA116Ra01 Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
LAA116Ra71 Biotin-Linked Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC.
MAA116Ra21 Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
Assay Kits SEA116Ra ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA116Gu01 Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA116Gu01 Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
MAA116Gu21 Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
Assay Kits SEA116Gu ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA116Si01 Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA116Si01 Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
LAA116Si71 Biotin-Linked Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC.
LAA116Si81 FITC-Linked Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA116Ca01 Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA116Ca01 Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
LAA116Ca71 Biotin-Linked Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC.
LAA116Ca81 FITC-Linked Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IF.
MAA116Ca21 Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA116Po01 Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA116Po01 Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
MAA116Po21 Monoclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
Assay Kits SEA116Po ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA116Bo01 Recombinant Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA116Bo01 Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IP.
LAA116Bo71 Biotin-Linked Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC.
LAA116Bo81 FITC-Linked Polyclonal Antibody to Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulated On Activation In Normal T-Cell Expressed And Secreted (RANTES) ELISA Kit Customized Service Offer
  1. "A human T cell-specific molecule is a member of a new gene family."J. Immunol. 141:1018-1025(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
  3. "A natural CCL5/RANTES variant antagonist for CCR1 and CCR3."Immunogenetics 58:533-541(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils."J. Exp. Med. 176:587-592(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Platelets secrete an eosinophil-chemotactic cytokine which is a member of the C-C-chemokine family."Adv. Exp. Med. Biol. 351:119-128(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells."Science 270:1811-1815(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection."J. Biol. Chem. 273:7222-7227(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Multiple pathways of amino terminal processing produce two truncated variants of RANTES/CCL5."J. Leukoc. Biol. 78:442-452(2005) [PubMed] [Europe PMC] [Abstract]
  10. "RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75."Br. J. Pharmacol. 149:490-497(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis."Diabetologia 56:2467-2476(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Proton NMR assignments and solution conformation of RANTES, a chemokine of the C-C type."Biochemistry 34:5329-5342(1995) [PubMed] [Europe PMC] [Abstract]
  13. "The three-dimensional solution structure of RANTES."Biochemistry 34:9307-9314(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein AOP-RANTES."Chem. Biol. 6:43-51(1999) [PubMed] [Europe PMC] [Abstract]
  15. "The crystal structure of Met-RANTES: comparison with native RANTES and AOP-RANTES."Protein Pept. Lett. 7:73-82(2000)