Placenta Growth Factor (PLGF)

[Edit]

PlGF2; PGF; PGFL; Placental Growth Factor-Like; Vascular Endothelial Growth Factor-Related Protein

Placenta Growth Factor (PLGF)

Placental growth factor (PLGF) is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PLGF during pregnancy is the placental trophoblast. PLGF is also expressed in many other tissues, including the villous trophoblast.

PLGF is a dimeric glycoprotein that, like VEGF, can bind with high affinity to the tyrosine kinase receptor vascular endothelial growth factor receptor 1 (VEGFR-1/Flt-1). PLGF/VEGF heterodimers have been isolated and shown to bind also to the VEGFR-2/KDR/Flk-1 receptor the major mediator of VEGF activities.PLGF shares approximately 42% amino acid (aa) sequence identity with VEGF (53% within the PDGF region), and the two proteins share significant structural similarity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA114Hu01 Recombinant Placenta Growth Factor (PLGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA114Hu01 Polyclonal Antibody to Placenta Growth Factor (PLGF) WB; IHC; ICC; IP.
MAA114Hu22 Monoclonal Antibody to Placenta Growth Factor (PLGF) WB; IHC; ICC; IP.
Assay Kits SEA114Hu ELISA Kit for Placenta Growth Factor (PLGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA114Mu01 Recombinant Placenta Growth Factor (PLGF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA114Mu02 Recombinant Placenta Growth Factor (PLGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA114Mu01 Polyclonal Antibody to Placenta Growth Factor (PLGF) WB; IHC; ICC; IP.
LAA114Mu81 FITC-Linked Polyclonal Antibody to Placenta Growth Factor (PLGF) WB; IHC; ICC; IF.
LAA114Mu71 Biotin-Linked Polyclonal Antibody to Placenta Growth Factor (PLGF) WB; IHC; ICC.
PAA114Mu02 Polyclonal Antibody to Placenta Growth Factor (PLGF) WB; IHC; ICC; IP.
Assay Kits SEA114Mu ELISA Kit for Placenta Growth Factor (PLGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA114Ra01 Recombinant Placenta Growth Factor (PLGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA114Ra01 Polyclonal Antibody to Placenta Growth Factor (PLGF) WB; IHC; ICC; IP.
MAA114Ra21 Monoclonal Antibody to Placenta Growth Factor (PLGF) WB; IHC; ICC; IP.
Assay Kits SEA114Ra ELISA Kit for Placenta Growth Factor (PLGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA114Bo01 Recombinant Placenta Growth Factor (PLGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA114Bo01 Polyclonal Antibody to Placenta Growth Factor (PLGF) WB; IHC; ICC; IP.
Assay Kits SEA114Bo ELISA Kit for Placenta Growth Factor (PLGF) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor."Proc. Natl. Acad. Sci. U.S.A. 88:9267-9271(1991) [PubMed] [Europe PMC] [Abstract]
  2. "A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta."Growth Factors 9:259-268(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14."Oncogene 8:925-931(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing."Biochem. Biophys. Res. Commun. 235:493-498(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR."J. Biol. Chem. 269:25646-25654(1994) [PubMed] [Europe PMC] [Abstract]
  8. "HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF." Cancer Cell 19:31-44(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution."J. Biol. Chem. 276:12153-12161(2001) [PubMed] [Europe PMC] [Abstract]