Neurotrophin 3 (NT3)

[Edit]

NTF3; HDNF; NGF2; Nerve Growth Factor 2; Neurotrophic Factor

Neurotrophin 3 (NT3)

Neurotrophin-3,or NT-3 is a protein that  is encoded by the NTF3 gene, NT-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor)-family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses.

NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic). NT-3 is unique in the number of neurons it can potentially stimulate, given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA106Hu01 Recombinant Neurotrophin 3 (NT3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA106Hu02 Recombinant Neurotrophin 3 (NT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA106Hu01 Polyclonal Antibody to Neurotrophin 3 (NT3) WB; IHC; ICC; IP.
MAA106Hu22 Monoclonal Antibody to Neurotrophin 3 (NT3) WB; IHC; ICC; IP.
PAA106Hu02 Polyclonal Antibody to Neurotrophin 3 (NT3) WB; IHC; ICC; IP.
LAA106Hu71 Biotin-Linked Polyclonal Antibody to Neurotrophin 3 (NT3) WB; IHC; ICC.
Assay Kits SEA106Hu ELISA Kit for Neurotrophin 3 (NT3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA106Hu CLIA Kit for Neurotrophin 3 (NT3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA106Mu01 Recombinant Neurotrophin 3 (NT3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA106Mu02 Recombinant Neurotrophin 3 (NT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA106Mu01 Polyclonal Antibody to Neurotrophin 3 (NT3) WB; IHC; ICC; IP.
PAA106Mu02 Polyclonal Antibody to Neurotrophin 3 (NT3) WB; IHC; ICC; IP.
Assay Kits SEA106Mu ELISA Kit for Neurotrophin 3 (NT3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA106Ra01 Recombinant Neurotrophin 3 (NT3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA106Ra02 Recombinant Neurotrophin 3 (NT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA106Ra01 Polyclonal Antibody to Neurotrophin 3 (NT3) WB; IHC; ICC; IP.
MAA106Ra21 Monoclonal Antibody to Neurotrophin 3 (NT3) WB; IHC; ICC; IP.
Assay Kits SEA106Ra ELISA Kit for Neurotrophin 3 (NT3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA106Po01 Recombinant Neurotrophin 3 (NT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA106Po01 Polyclonal Antibody to Neurotrophin 3 (NT3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Neurotrophin 3 (NT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurotrophin 3 (NT3) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA106Bo01 Recombinant Neurotrophin 3 (NT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA106Bo01 Polyclonal Antibody to Neurotrophin 3 (NT3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Neurotrophin 3 (NT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurotrophin 3 (NT3) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA106Ga01 Recombinant Neurotrophin 3 (NT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA106Ga01 Polyclonal Antibody to Neurotrophin 3 (NT3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Neurotrophin 3 (NT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurotrophin 3 (NT3) ELISA Kit Customized Service Offer

Organism species: Xenopus (Clawed frog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurotrophin 3 (NT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurotrophin 3 (NT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurotrophin 3 (NT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neurotrophin 3 (NT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurotrophin 3 (NT3) ELISA Kit Customized Service Offer
  1. "Cloning and expression of a cDNA encoding a novel human neurotrophic factor."FEBS Lett. 266:187-191(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structure and biological activity of a novel human neurotrophic factor."Neuron 4:767-773(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of a human gene that is a member of the nerve growth factor family."Proc. Natl. Acad. Sci. U.S.A. 87:8060-8064(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer."Biochemistry 34:4139-4146(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Association of neurotrophin-3 gene variant with severe forms of schizophrenia."Biochem. Biophys. Res. Commun. 209:513-518(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Failure to find associations of the CA repeat polymorphism in the first intron and the Gly-63/Glu-63 polymorphism of the neurotrophin-3 gene with schizophrenia."Psychiatr. Genet. 6:13-15(1996) [PubMed] [Europe PMC] [Abstract]