Matrix Metalloproteinase 7 (MMP7)

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MPSL1; MAT; PUMP-1; Matrilysin Uterine; Matrilysin; Matrin; Pump-1 Protease; Uterine Metalloproteinase

Matrix Metalloproteinase 7 (MMP7)

MMP7, also known as Matrilysin, is the smallest member of the MMP-family, it is a zinc-dependent metalloproteinase and is overexpressed in colon cancer and many other human cancers. MMP7 is a secreted matrix metalloproteinase, which contributes to angiogenesis by breaking down basement membranes. Matrix Metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components.

MMP7 is responsible for hydrolyzing proteoglycans and ECM glycoproteins. It is expressed in normal cells, specifically glandular epithelial cells. MMP7, is thought to play an important role in the early steps of tumor progression. Expression of MMP2, MMP7 and MMP11 is greater in pancreatic carcinoma than in normal pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA102Hu01 Recombinant Matrix Metalloproteinase 7 (MMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA102Hu01 Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
MAA102Hu22 Monoclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
Assay Kits SEA102Hu ELISA Kit for Matrix Metalloproteinase 7 (MMP7) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA102Hu CLIA Kit for Matrix Metalloproteinase 7 (MMP7) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA102Mu01 Recombinant Matrix Metalloproteinase 7 (MMP7) Positive Control; Immunogen; SDS-PAGE; WB.
RPA102Mu02 Recombinant Matrix Metalloproteinase 7 (MMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA102Mu01 Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
PAA102Mu02 Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
Assay Kits SEA102Mu ELISA Kit for Matrix Metalloproteinase 7 (MMP7) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA102Mu CLIA Kit for Matrix Metalloproteinase 7 (MMP7) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA102Ra01 Recombinant Matrix Metalloproteinase 7 (MMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA102Ra01 Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
MAA102Ra21 Monoclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
Assay Kits SEA102Ra ELISA Kit for Matrix Metalloproteinase 7 (MMP7) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA102Ra CLIA Kit for Matrix Metalloproteinase 7 (MMP7) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA102Bo01 Recombinant Matrix Metalloproteinase 7 (MMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA102Bo01 Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
MAA102Bo21 Monoclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
Assay Kits SEA102Bo ELISA Kit for Matrix Metalloproteinase 7 (MMP7) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA102Bo CLIA Kit for Matrix Metalloproteinase 7 (MMP7) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA102Cp01 Recombinant Matrix Metalloproteinase 7 (MMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA102Cp01 Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
MAA102Cp21 Monoclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
Assay Kits SEA102Cp ELISA Kit for Matrix Metalloproteinase 7 (MMP7) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA102Cp CLIA Kit for Matrix Metalloproteinase 7 (MMP7) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA102Eq01 Recombinant Matrix Metalloproteinase 7 (MMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA102Eq01 Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
MAA102Eq21 Monoclonal Antibody to Matrix Metalloproteinase 7 (MMP7) WB; IHC; ICC; IP.
Assay Kits SEA102Eq ELISA Kit for Matrix Metalloproteinase 7 (MMP7) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA102Eq CLIA Kit for Matrix Metalloproteinase 7 (MMP7) Chemiluminescent immunoassay for Antigen Detection.
  1. "The collagenase gene family in humans consists of at least four members."Biochem. J. 253:187-192(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1."Biochem. J. 285:899-905(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and expression of the human gene for the matrix metalloproteinase matrilysin."J. Biol. Chem. 269:2032-2040(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line."Cancer Res. 50:7758-7764(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members."Biochemistry 28:5327-5334(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Matrilysin-inhibitor complexes: common themes among metalloproteases."Biochemistry 34:6602-6610(1995) [PubMed] [Europe PMC] [Abstract]