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Matrix Metalloproteinase 2 (MMP2)

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CLG4; CLG4A; MMP-II; MONA; TBE-1; PEX; Gelatinase A; 72kDa Gelatinase; 72kDa Type IV Collagenase

Matrix Metalloproteinase 2 (MMP2)
CCC A100
HGNC 7166
MGI 97009
PubMed 11431697
RGD 621316
UniProt P08253
Wiki MMP2

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA100Hu01 Recombinant Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA100Hu02 Recombinant Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
APA100Hu02 Active Matrix Metalloproteinase 2 (MMP2) Cell culture; Activity Assays.
APA100Hu01 Active Matrix Metalloproteinase 2 (MMP2) Cell culture; Activity Assays.
EPA100Hu61 Eukaryotic Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
EPA100Hu62 Eukaryotic Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
APA100Hu61 Active Matrix Metalloproteinase 2 (MMP2) Cell culture; Activity Assays.
APA100Hu62 Active Matrix Metalloproteinase 2 (MMP2) Cell culture; Activity Assays.
RPA100Hu03 Recombinant Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA100Hu01 Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
MAA100Hu22 Monoclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC
PAA100Hu02 Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
LAA100Hu71 Biotin-Linked Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC.
LAA100Hu81 FITC-Linked Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IF.
MAA100Hu23 Monoclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
MAA100Hu26 Monoclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
MAA100Hu27 Monoclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
MAA100Hu21 Monoclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
Assay Kits SEA100Hu ELISA Kit for Matrix Metalloproteinase 2 (MMP2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA100Hu CLIA Kit for Matrix Metalloproteinase 2 (MMP2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA100Mu01 Recombinant Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA100Mu02 Recombinant Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
APA100Mu01 Active Matrix Metalloproteinase 2 (MMP2) Cell culture; Activity Assays.
Antibodies PAA100Mu01 Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
PAA100Mu02 Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
Assay Kits SEA100Mu ELISA Kit for Matrix Metalloproteinase 2 (MMP2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA100Mu CLIA Kit for Matrix Metalloproteinase 2 (MMP2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA100Ra01 Recombinant Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA100Ra01 Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
MAA100Ra21 Monoclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
PAA100Ra02 Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
Assay Kits SEA100Ra ELISA Kit for Matrix Metalloproteinase 2 (MMP2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA100Ra CLIA Kit for Matrix Metalloproteinase 2 (MMP2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA100Rb01 Recombinant Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA100Rb51 Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
MAA100Rb21 Monoclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
Assay Kits SEA100Rb ELISA Kit for Matrix Metalloproteinase 2 (MMP2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA100Rb CLIA Kit for Matrix Metalloproteinase 2 (MMP2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA100Po01 Recombinant Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA100Po01 Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
MAA100Po21 Monoclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
Assay Kits SEA100Po ELISA Kit for Matrix Metalloproteinase 2 (MMP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Matrix Metalloproteinase 2 (MMP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Matrix Metalloproteinase 2 (MMP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) Polyclonal Antibody Customized Service Offer
Assay Kits SEA100Bo ELISA Kit for Matrix Metalloproteinase 2 (MMP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA100Eq01 Recombinant Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA100Eq01 Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
MAA100Eq21 Monoclonal Antibody to Matrix Metalloproteinase 2 (MMP2) WB; IHC; ICC; IP.
Assay Kits SEA100Eq ELISA Kit for Matrix Metalloproteinase 2 (MMP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA100Ga01 Recombinant Matrix Metalloproteinase 2 (MMP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Matrix Metalloproteinase 2 (MMP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Matrix Metalloproteinase 2 (MMP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Matrix Metalloproteinase 2 (MMP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Matrix Metalloproteinase 2 (MMP2) ELISA Kit Customized Service Offer
  1. "Structure of the human type IV collagenase gene."J. Biol. Chem. 265:11077-11082(1990) [PubMed] [Europe PMC] [Abstract]
  2. "On the structure and chromosome location of the 72- and 92-kDa human type IV collagenase genes."Genomics 9:429-434(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Completion of the primary structure of the human type IV collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16."Genomics 6:554-559(1990) [PubMed] [Europe PMC] [Abstract]
  7. "H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen."J. Biol. Chem. 263:6579-6587(1988) [PubMed] [Europe PMC] [Abstract]
  8. "TIMP-2: identification and characterization of a new member of the metalloproteinase inhibitor family."Matrix Suppl. 1:299-306(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site."J. Biol. Chem. 266:17972-17977(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3."Cell 85:683-693(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases."Eur. J. Biochem. 244:653-657(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity."Cell 92:391-400(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor."Circ. Res. 85:906-911(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction."Circ. Res. 87:670-676(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Simultaneous inhibition of glioma angiogenesis, cell proliferation, and invasion by a naturally occurring fragment of human metalloproteinase-2."Cancer Res. 61:8730-8736(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease."Infect. Immun. 69:1402-1408(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity."J. Cancer Res. Clin. Oncol. 127:653-658(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy."Invest. Ophthalmol. Vis. Sci. 44:2163-2170(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases."Oncogene 22:4617-4626(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro."FASEB J. 18:690-692(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation."FASEB J. 21:2486-2495(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts."Cardiovasc. Res. 83:698-706(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes."Pharmacology 83:18-25(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  25. "A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity."PLoS ONE 7:E34177-E34177(2012) [PubMed] [Europe PMC] [Abstract]
  26. "Crystal structure of the haemopexin-like C-terminal domain of gelatinase A."Nat. Struct. Biol. 2:938-942(1995) [PubMed] [Europe PMC] [Abstract]
  27. "The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function."FEBS Lett. 378:126-130(1996) [PubMed] [Europe PMC] [Abstract]
  28. "Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed."Science 284:1667-1670(1999) [PubMed] [Europe PMC] [Abstract]
  29. "The second type II module from human matrix metalloproteinase 2: structure, function and dynamics."Structure 7:1235-1245(1999) [PubMed] [Europe PMC] [Abstract]
  30. "Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct."J. Biol. Chem. 276:27613-27621(2001) [PubMed] [Europe PMC] [Abstract]
  31. "Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor."Biochim. Biophys. Acta 1598:10-23(2002) [PubMed] [Europe PMC] [Abstract]
  32. "The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains."Biol. Chem. 383:137-148(2002) [PubMed] [Europe PMC] [Abstract]
  33. "Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2."Proc. Natl. Acad. Sci. U.S.A. 99:7414-7419(2002) [PubMed] [Europe PMC] [Abstract]
  34. "Matrix metalloproteinase target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis."J. Med. Chem. 49:51-69(2006) [PubMed] [Europe PMC] [Abstract]
  35. "Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome."Nat. Genet. 28:261-265(2001) [PubMed] [Europe PMC] [Abstract]
  36. "Winchester syndrome caused by a homozygous mutation affecting the active site of matrix metalloproteinase 2."Clin. Genet. 67:261-266(2005) [PubMed] [Europe PMC] [Abstract]
  37. "A novel homozygous MMP2 mutation in a family with Winchester syndrome."Clin. Genet. 69:271-276(2006) [PubMed] [Europe PMC] [Abstract]
  38. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]