Matrix Metalloproteinase 13 (MMP13)

MMP-13 has been proposed to participate in aggrecan degradation associated with osteoarthritis and cleavage of type II collagen in osteoarthritic cartilage explants and in tumor progression and metastasis . In addition, it can cleave type I, III, IV, IX, X and XIV collagens and fibronectin. MMP-13 is likely to play a crucial role in the modulation of extracellular matrix degradation and cell-matrix interactions .MMP-13 is expressed by several metastatic tumors including breast carcinomas, chondrosarcomas, head and neck carcinomas, and in degenerative bone diseases including rheumatoid arthritis. Wild type and mutant p53, a tumor suppressor gene, differentially regulate MMP-13 gene expression . Members of the activator protein-1 and core-binding factor families increase MMP-13 promoter activity in normal, differentiating osteoblasts .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Hu01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
RPA099Hu02 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
APA099Hu02 Active Matrix Metalloproteinase 13 (MMP13) Cell culture; Activity Assays.
Antibodies PAA099Hu01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Hu22 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
PAA099Hu02 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
LAA099Hu71 Biotin-Linked Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC.
Assay Kits SEA099Hu ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Hu CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.
HEA099Hu High Sensitive ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Mu01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
RPA099Mu02 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Mu01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
PAA099Mu02 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
LAA099Mu71 Biotin-Linked Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC.
Assay Kits SEA099Mu ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Mu CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.
HEA099Mu High Sensitive ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Ra01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
RPA099Ra02 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
EPA099Ra61 Eukaryotic Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
APA099Ra61 Active Matrix Metalloproteinase 13 (MMP13) Cell culture; Activity Assays.
Antibodies PAA099Ra01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
PAA099Ra02 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
LAA099Ra71 Biotin-Linked Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC.
Assay Kits SEA099Ra ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Ra CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Rb01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
RPA099Rb02 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
RPA099Rb03 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Rb53 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
PAA099Rb51 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
PAA099Rb52 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
LAA099Rb71 Biotin-Linked Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC.
LAA099Rb81 FITC-Linked Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IF.
Assay Kits SEA099Rb ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Rb CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Ca01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Ca01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Matrix Metalloproteinase 13 (MMP13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Matrix Metalloproteinase 13 (MMP13) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Po01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Po01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Po21 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits SEA099Po ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Po CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Bo01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Bo01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Bo21 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits SEA099Bo ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Bo CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Cp01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Cp01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Cp21 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits SEA099Cp ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Cp CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Eq01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Eq01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Eq21 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits SEA099Eq ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Eq CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA099Ga01 Recombinant Matrix Metalloproteinase 13 (MMP13) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA099Ga01 Polyclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
MAA099Ga21 Monoclonal Antibody to Matrix Metalloproteinase 13 (MMP13) WB; IHC; ICC; IP.
Assay Kits SEA099Ga ELISA Kit for Matrix Metalloproteinase 13 (MMP13) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA099Ga CLIA Kit for Matrix Metalloproteinase 13 (MMP13) Chemiluminescent immunoassay for Antigen Detection.
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  9. "Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development."Dev. Dyn. 208:387-397(1997) [PubMed] [Europe PMC] [Abstract]
  10. "The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction."J. Biol. Chem. 272:7608-7616(1997) [PubMed] [Europe PMC] [Abstract]
  11. "A secreted tyrosine kinase acts in the extracellular environment."Cell 158:1033-1044(2014) [PubMed] [Europe PMC] [Abstract]
  12. "The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain."J. Mol. Biol. 264:556-566(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors."Nat. Struct. Biol. 6:217-221(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1."J. Mol. Biol. 301:513-524(2000) [PubMed] [Europe PMC] [Abstract]
  15. "High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor."J. Mol. Biol. 302:671-689(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14." Bioorg. Med. Chem. Lett. 15:1807-1810(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Structural basis for the highly selective inhibition of MMP-13."Chem. Biol. 12:181-189(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects."J. Biol. Chem. 282:27781-27791(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2."J. Mol. Biol. 366:1222-1231(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13." J. Med. Chem. 52:3523-3538(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis." Bioorg. Med. Chem. Lett. 20:576-580(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease." J. Med. Chem. 53:6653-6680(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins."J. Biol. Chem. 287:26647-26656(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Hydantoin based inhibitors of MMP13--discovery of AZD6605."Bioorg. Med. Chem. Lett. 23:4705-4712(2013) [PubMed] [Europe PMC] [Abstract]
  25. "Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain."FASEB J. 27:4395-4405(2013) [PubMed] [Europe PMC] [Abstract]
  26. "MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO)."J. Clin. Invest. 115:2832-2842(2005) [PubMed] [Europe PMC] [Abstract]
  27. "Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia."Am. J. Hum. Genet. 85:168-178(2009) [PubMed] [Europe PMC] [Abstract]