Caspase 11 (CASP11)

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SRSF2IP; SFRS2IP; SIP1; SRRP129; Cysteinyl Aspartate Specific Proteinases 11; Apoptosis-Related Cysteine Peptidase 11; Splicing Factor,Arginine/Serine-Rich 2,Interacting

Caspase 11 (CASP11)

This enzyme is a member of a family of evolutionarily conserved cysteine protease proteins known as caspases. Many of these enzymes are part of a proteolytic cascade that plays a central role in cell death by apoptosis. Caspase-11 has been isolated and characterized as ICH-3 [ICE and CED3 homolog-3]. Caspase-11 gene expression in response to bacterial lipopolysaccharides and IFN-gamma requires NF-kappa-B and the signal transducer STAT1 .

By performing a yeast 2-hybrid assay to identify proteins that interact with CTD, Tanner et al. (1997) isolated partial cDNAs encoding SIP1, which they called CTD-associated SR protein 11 (CASP11) or SR-related protein of 129 kD (SRrp129). Northern blot analysis detected expression of the approximately 6-kb SRrp129 mRNA in all tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA094Hu01 Recombinant Caspase 11 (CASP11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA094Hu01 Polyclonal Antibody to Caspase 11 (CASP11) WB; IHC; ICC; IP.
Assay Kits SEA094Hu ELISA Kit for Caspase 11 (CASP11) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA094Mu01 Recombinant Caspase 11 (CASP11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA094Mu01 Polyclonal Antibody to Caspase 11 (CASP11) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Caspase 11 (CASP11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 11 (CASP11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caspase 11 (CASP11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caspase 11 (CASP11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caspase 11 (CASP11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caspase 11 (CASP11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 11 (CASP11) ELISA Kit Customized Service Offer
  1. "A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain."Biol. Chem. 378:565-571(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing."Mol. Cell. Biol. 18:676-684(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]