≡

Interleukin 1 Receptor Type II (IL1R2)

[Edit]

CD121b; CD121-B; IL1-R2; IL1RB; Interleukin-1 Receptor Beta; CD121 Antigen-like Family Member B

Interleukin 1 Receptor Type II (IL1R2)
CCC A065
HGNC 5994
MGI 96546
PubMed 19401759
RGD 621147
UniProt P27930
Wiki IL1R2

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family.

This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA065Hu01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA065Hu01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
MAA065Hu22 Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
Assay Kits SEA065Hu ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA065Mu01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA065Mu02 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA065Mu01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
PAA065Mu02 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
Assay Kits SEA065Mu ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA065Ra01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA065Ra01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) ELISA Kit Customized Service Offer

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA065Si01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA065Si01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
MAA065Si21 Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
Assay Kits SEA065Si ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types."EMBO J. 10:2821-2832(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA."J. Biol. Chem. 271:20965-20972(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses."J. Immunol. 153:5802-5809(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist."Proc. Natl. Acad. Sci. U.S.A. 92:1714-1718(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Role of metalloproteases in the release of the IL-1 type II decoy receptor."J. Biol. Chem. 272:31764-31769(1997) [PubMed] [Europe PMC] [Abstract]
  8. "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness."J. Immunol. 161:6871-6877(1998) [PubMed] [Europe PMC] [Abstract]
  9. "The membrane form of the type II IL-1 receptor accounts for inhibitory function."J. Immunol. 165:3350-3357(2000) [PubMed] [Europe PMC] [Abstract]
  10. "The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action."Immunity 18:87-96(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Structural insights into the assembly and activation of IL-1beta with its receptors."Nat. Immunol. 11:905-911(2010) [PubMed] [Europe PMC] [Abstract]