Interleukin 11 (IL11)

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AGIF; Adipogenesis Inhibitory Factor; Oprelvekin

Interleukin 11 (IL11)

Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.
Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of IL-11. The cytokine also possesses anti-inflammatory activity, and has been proposed as a therapeutic agent in the treatment of chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA057Hu01 Recombinant Interleukin 11 (IL11) Positive Control; Immunogen; SDS-PAGE; WB.
EPA057Hu61 Eukaryotic Interleukin 11 (IL11) Positive Control; Immunogen; SDS-PAGE; WB.
APA057Hu61 Active Interleukin 11 (IL11) Cell culture; Activity Assays.
APA057Hu01 Active Interleukin 11 (IL11) Cell culture; Activity Assays.
Antibodies PAA057Hu01 Polyclonal Antibody to Interleukin 11 (IL11) WB; IHC; ICC; IP.
MAA057Hu22 Monoclonal Antibody to Interleukin 11 (IL11) WB; IHC; ICC; IP.
Assay Kits SEA057Hu ELISA Kit for Interleukin 11 (IL11) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA057Mu01 Recombinant Interleukin 11 (IL11) Positive Control; Immunogen; SDS-PAGE; WB.
RPA057Mu02 Recombinant Interleukin 11 (IL11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA057Mu01 Polyclonal Antibody to Interleukin 11 (IL11) WB; IHC; ICC; IP.
PAA057Mu02 Polyclonal Antibody to Interleukin 11 (IL11) WB; IHC; ICC; IP.
Assay Kits SEA057Mu ELISA Kit for Interleukin 11 (IL11) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA057Mu CLIA Kit for Interleukin 11 (IL11) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA057Ra01 Recombinant Interleukin 11 (IL11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA057Ra01 Polyclonal Antibody to Interleukin 11 (IL11) WB; IHC; ICC; IP.
MAA057Ra21 Monoclonal Antibody to Interleukin 11 (IL11) WB; IHC; ICC; IP.
Assay Kits SEA057Ra ELISA Kit for Interleukin 11 (IL11) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine."Proc. Natl. Acad. Sci. U.S.A. 87:7512-7516(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11."FEBS Lett. 283:199-202(1991) [PubMed] [Europe PMC] [Abstract]
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  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of a potent human interleukin-11 agonist."Biochem. J. 375:23-32(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6."Acta Crystallogr. D 70:2277-2285(2014) [PubMed] [Europe PMC] [Abstract]