Glial Cell Line Derived Neurotrophic Factor (GDNF)

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ATF1; ATF2; HFB1-GDNF; Astrocyte-Derived Trophic Factor; Glial Derived Neurotrophic Factor

Glial Cell Line Derived Neurotrophic Factor (GDNF)

Glial Cell Line-derived Neurotrophic Factor (GDNF) is a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy.

The protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA043Hu01 Recombinant Glial Cell Line Derived Neurotrophic Factor (GDNF) Positive Control; Immunogen; SDS-PAGE; WB.
APA043Hu01 Active Glial Cell Line Derived Neurotrophic Factor (GDNF) Cell culture; Activity Assays.
Antibodies PAA043Hu01 Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor (GDNF) WB; IHC; ICC; IP.
MAA043Hu22 Monoclonal Antibody to Glial Cell Line Derived Neurotrophic Factor (GDNF) WB; IHC; ICC; IP.
LAA043Hu71 Biotin-Linked Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor (GDNF) WB; IHC; ICC.
LAA043Hu81 FITC-Linked Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor (GDNF) WB; IHC; ICC; IF.
Assay Kits SEA043Hu ELISA Kit for Glial Cell Line Derived Neurotrophic Factor (GDNF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA043Hu CLIA Kit for Glial Cell Line Derived Neurotrophic Factor (GDNF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA043Mu01 Recombinant Glial Cell Line Derived Neurotrophic Factor (GDNF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA043Mu02 Recombinant Glial Cell Line Derived Neurotrophic Factor (GDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA043Mu01 Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor (GDNF) WB; IHC; ICC; IP.
LAA043Mu71 Biotin-Linked Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor (GDNF) WB; IHC; ICC.
PAA043Mu02 Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor (GDNF) WB; IHC; ICC; IP.
Assay Kits SEA043Mu ELISA Kit for Glial Cell Line Derived Neurotrophic Factor (GDNF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA043Mu CLIA Kit for Glial Cell Line Derived Neurotrophic Factor (GDNF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA043Ra01 Recombinant Glial Cell Line Derived Neurotrophic Factor (GDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA043Ra01 Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor (GDNF) WB; IHC; ICC; IP.
MAA043Ra21 Monoclonal Antibody to Glial Cell Line Derived Neurotrophic Factor (GDNF) WB; IHC; ICC; IP.
Assay Kits SEA043Ra ELISA Kit for Glial Cell Line Derived Neurotrophic Factor (GDNF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA043Ra CLIA Kit for Glial Cell Line Derived Neurotrophic Factor (GDNF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glial Cell Line Derived Neurotrophic Factor (GDNF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glial Cell Line Derived Neurotrophic Factor (GDNF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glial Cell Line Derived Neurotrophic Factor (GDNF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glial Cell Line Derived Neurotrophic Factor (GDNF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glial Cell Line Derived Neurotrophic Factor (GDNF) ELISA Kit Customized Service Offer
  1. "GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons."Science 260:1130-1132(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Multiple astrocyte transcripts encode nigral trophic factors in rat and human."Exp. Neurol. 130:387-393(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of a promoter for the human glial cell line-derived neurotrophic factor gene."Brain Res. Mol. Brain Res. 69:209-222(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of the human GDNF gene reveals an inducible promoter, three exons, a triplet repeat within the 3'-UTR and alternative splice products."Hum. Mol. Genet. 7:1873-1886(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Glial cell line-derived neurotrophic factor: selective reduction of the intermolecular disulfide linkage and characterization of its disulfide structure."Biochemistry 35:16799-16805(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease."J. Biol. Chem. 286:45093-45102(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype."Eur. J. Hum. Genet. 5:180-185(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling."Acta Crystallogr. F 65:551-558(2009) [PubMed] [Europe PMC] [Abstract]
  11. "De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease."Hum. Mol. Genet. 5:2023-2026(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient."Nat. Genet. 14:341-344(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Germline mutations of the RET ligand GDNF are not sufficient to cause Hirschsprung disease."Nat. Genet. 14:345-347(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations of the RET-GDNF signaling pathway in Ondine's curse."Am. J. Hum. Genet. 62:715-717(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Pathogenesis of Hirschsprung's disease."J. Pediatr. Surg. 35:1017-1025(2000) [PubMed] [Europe PMC] [Abstract]