Factor Related Apoptosis Ligand (FASL)

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CD178; CD95L; CD95-L; FASLG; FASLG; APT1LG1; APT1-LG1; TNFSF6; Fas Antigen Ligand; TNF Superfamily Member 6; Tumor Necrosis Factor(ligand)Superfamily,Member 6

Factor Related Apoptosis Ligand (FASL)

Fas ligand is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. The binding of Fas ligand with its receptor induces apoptosis. Fas ligand-receptor interactions play an important role in the regulation of the immune system and the progression of cancer.Fas ligand or FasL is a type II transmembrane protein.

Fas ligand is a homotrimeric protein and signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death.Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external serine matrix metalloproteinase MMP-7. Soluble FasL is less active than their membrane-bound counterparts and do not induce receptor trimerization and DISC formation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA031Hu01 Recombinant Factor Related Apoptosis Ligand (FASL) Positive Control; Immunogen; SDS-PAGE; WB.
RPA031Hu02 Recombinant Factor Related Apoptosis Ligand (FASL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA031Hu01 Polyclonal Antibody to Factor Related Apoptosis Ligand (FASL) WB; IHC; ICC; IP.
MAA031Hu22 Monoclonal Antibody to Factor Related Apoptosis Ligand (FASL) WB; IHC; ICC; IP.
LAA031Hu71 Biotin-Linked Polyclonal Antibody to Factor Related Apoptosis Ligand (FASL) WB; IHC; ICC.
PAA031Hu02 Polyclonal Antibody to Factor Related Apoptosis Ligand (FASL) WB; IHC; ICC; IP.
Assay Kits SEA031Hu ELISA Kit for Factor Related Apoptosis Ligand (FASL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA031Mu01 Recombinant Factor Related Apoptosis Ligand (FASL) Positive Control; Immunogen; SDS-PAGE; WB.
RPA031Mu02 Recombinant Factor Related Apoptosis Ligand (FASL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA031Mu01 Polyclonal Antibody to Factor Related Apoptosis Ligand (FASL) WB; IHC; ICC; IP.
PAA031Mu02 Polyclonal Antibody to Factor Related Apoptosis Ligand (FASL) WB; IHC; ICC; IP.
Assay Kits SEA031Mu ELISA Kit for Factor Related Apoptosis Ligand (FASL) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA031Mu CLIA Kit for Factor Related Apoptosis Ligand (FASL) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA031Ra01 Recombinant Factor Related Apoptosis Ligand (FASL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA031Ra01 Polyclonal Antibody to Factor Related Apoptosis Ligand (FASL) WB; IHC; ICC; IP.
Assay Kits SEA031Ra ELISA Kit for Factor Related Apoptosis Ligand (FASL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA031Si01 Recombinant Factor Related Apoptosis Ligand (FASL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA031Si01 Polyclonal Antibody to Factor Related Apoptosis Ligand (FASL) WB; IHC; ICC; IP.
LAA031Si71 Biotin-Linked Polyclonal Antibody to Factor Related Apoptosis Ligand (FASL) WB; IHC; ICC.
LAA031Si81 FITC-Linked Polyclonal Antibody to Factor Related Apoptosis Ligand (FASL) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Factor Related Apoptosis Ligand (FASL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Factor Related Apoptosis Ligand (FASL) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA031Po01 Recombinant Factor Related Apoptosis Ligand (FASL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA031Po01 Polyclonal Antibody to Factor Related Apoptosis Ligand (FASL) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Factor Related Apoptosis Ligand (FASL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Factor Related Apoptosis Ligand (FASL) ELISA Kit Customized Service Offer
  1. "Fas ligand mediates activation-induced cell death in human T lymphocytes."J. Exp. Med. 181:71-77(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Human Fas ligand: gene structure, chromosomal location and species specificity."Int. Immunol. 6:1567-1574(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Role of Fas ligand in apoptosis induced by hepatitis C virus infection."Biochem. Biophys. Res. Commun. 204:468-474(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease."J. Clin. Invest. 98:1107-1113(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of Fas (Apo-1, CD95)-Fas ligand interaction."J. Biol. Chem. 272:18827-18833(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Downregulation of Fas ligand by shedding."Nat. Med. 4:31-36(1998) [PubMed] [Europe PMC] [Abstract]
  9. "The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells."Cell Death Differ. 14:1678-1687(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation."J. Cell Sci. 120:191-199(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]