Erythropoietin Receptor (EPOR)

Erythropoietin receptor(EPOR) is a 66 kDa peptide and is a member of the cytokine receptor superfamily that contains aW-S-X-W-S motif and four cysteine residues in the extracellar domain. Erythropoietin (EPO) is the regulator of red blood cell formation. Its receptor (EPOR) is now found in many cells and tissues of the body. EpoR is also shown to occur in tumor cells and Epo enhances the proliferation of these cells through cell signaling. EPOR antagonist can reduce the growth of the tumor in vivo. EpoR is expressed in high or low affinity forms, but the high-affinity receptor is likely the more physiologically relevant class. A peak in EpoR expression occurs on erythroid progenitor cells at the CFU-E/proerythroblast stage, but subsequently decreases following maturation and differentation; EpoR cannot be detected on reticulocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA027Hu01 Recombinant Erythropoietin Receptor (EPOR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA027Hu02 Recombinant Erythropoietin Receptor (EPOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA027Hu01 Polyclonal Antibody to Erythropoietin Receptor (EPOR) WB; IHC; ICC; IP.
MAA027Hu22 Monoclonal Antibody to Erythropoietin Receptor (EPOR) WB; IHC; ICC; IP.
LAA027Hu81 FITC-Linked Polyclonal Antibody to Erythropoietin Receptor (EPOR) WB; IHC; ICC; IF.
LAA027Hu71 Biotin-Linked Polyclonal Antibody to Erythropoietin Receptor (EPOR) WB; IHC; ICC.
PAA027Hu02 Polyclonal Antibody to Erythropoietin Receptor (EPOR) WB; IHC; ICC; IP.
Assay Kits SEA027Hu ELISA Kit for Erythropoietin Receptor (EPOR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA027Mu01 Recombinant Erythropoietin Receptor (EPOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA027Mu01 Polyclonal Antibody to Erythropoietin Receptor (EPOR) WB; IHC; ICC; IP.
LAA027Mu71 Biotin-Linked Polyclonal Antibody to Erythropoietin Receptor (EPOR) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Erythropoietin Receptor (EPOR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Erythropoietin Receptor (EPOR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA027Ra01 Recombinant Erythropoietin Receptor (EPOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA027Ra01 Polyclonal Antibody to Erythropoietin Receptor (EPOR) WB; IHC; ICC; IP.
LAA027Ra71 Biotin-Linked Polyclonal Antibody to Erythropoietin Receptor (EPOR) WB; IHC; ICC.
MAA027Ra21 Monoclonal Antibody to Erythropoietin Receptor (EPOR) WB; IHC; ICC; IP.
Assay Kits SEA027Ra ELISA Kit for Erythropoietin Receptor (EPOR) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p."Blood 76:24-30(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Human erythropoietin receptor: cloning, expression, and biologic characterization."Blood 76:31-35(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of the human erythropoietin receptor gene."Blood 78:2548-2556(1991) [PubMed] [Europe PMC] [Abstract]
  4. "The erythropoietin receptor gene: cloning and identification of multiple transcripts in an erythroid cell line OCIM1."Exp. Hematol. 19:973-977(1991) [PubMed] [Europe PMC] [Abstract]
  5. "A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells."Science 257:1138-1141(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Cloning of the gene encoding the human erythropoietin receptor."Blood 78:2557-2563(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Genomic organization of the human erythropoietin receptor gene."Genomics 11:974-980(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Isolation of a cDNA encoding a potential soluble receptor for human erythropoietin."Gene 106:283-284(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation."Blood 99:102-110(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways."J. Biol. Chem. 270:5631-5635(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of a critical ligand binding determinant of the human erythropoietin receptor. Evidence for common ligand binding motifs in the cytokine receptor family."J. Biol. Chem. 271:14045-14054(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Increased cell surface expression of C-terminal truncated erythropoietin receptors in polycythemia."Eur. J. Haematol. 67:88-93(2001) [PubMed] [Europe PMC] [Abstract]
  15. "A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor."Eur. J. Biochem. 269:2516-2526(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Erythropoietin receptors associate with a ubiquitin ligase, p33RUL, and require its activity for erythropoietin-induced proliferation."J. Biol. Chem. 278:26851-26861(2003) [PubMed] [Europe PMC] [Abstract]
  17. "APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl."Leukemia 13:760-767(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Cloning and characterization of a family of proteins associated with Mpl."J. Biol. Chem. 277:9139-9147(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A."Science 273:464-471(1996) [PubMed] [Europe PMC] [Abstract]
  20. "An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation."Nat. Struct. Biol. 5:993-1004(1998) [PubMed] [Europe PMC] [Abstract]
  21. "Efficiency of signalling through cytokine receptors depends critically on receptor orientation."Nature 395:511-516(1998) [PubMed] [Europe PMC] [Abstract]
  22. "Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin."Protein Eng. 12:505-513(1999) [PubMed] [Europe PMC] [Abstract]
  23. "Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation."Science 283:987-990(1999) [PubMed] [Europe PMC] [Abstract]
  24. "Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis."Proc. Natl. Acad. Sci. U.S.A. 90:4495-4499(1993) [PubMed] [Europe PMC] [Abstract]
  25. "Mutation in the negative regulatory element of the erythropoietin receptor gene in a case of sporadic primary polycythemia."Exp. Hematol. 22:447-453(1994) [PubMed] [Europe PMC] [Abstract]
  26. "Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies."Blood 87:1502-1511(1996) [PubMed] [Europe PMC] [Abstract]