Eosinophil Chemotactic Factor (ECF)

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CCL11; SCYA11; Eotaxin 1; Eosinophil Chemotactic Protein 1; Chemokine C-C-Motif Ligand 11; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 11

Eosinophil Chemotactic Factor (ECF)

An eosinophil chemotactic factor (ECF) can be released from human polymorphonuclear neutrophils (PMN), rat mononuclear and rat mast cells by the calcium ionophore, during phagocytosis, by arachidonic acid and phospholipase A2. It has been suggested that stimuli such as the ionophore and the phagocytic event lead to phospholipid turnover with the generation of arachidonic acid which is subsequently transformed by a lipoxygenase-like enzyme into ECF. 

Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA025Hu01 Recombinant Eosinophil Chemotactic Factor (ECF) Positive Control; Immunogen; SDS-PAGE; WB.
APA025Hu01 Active Eosinophil Chemotactic Factor (ECF) Cell culture; Activity Assays.
Antibodies PAA025Hu01 Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
MAA025Hu22 Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
Assay Kits SEA025Hu ELISA Kit for Eosinophil Chemotactic Factor (ECF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA025Hu CLIA Kit for Eosinophil Chemotactic Factor (ECF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA025Mu01 Recombinant Eosinophil Chemotactic Factor (ECF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA025Mu02 Recombinant Eosinophil Chemotactic Factor (ECF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA025Mu01 Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
PAA025Mu02 Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
Assay Kits SEA025Mu ELISA Kit for Eosinophil Chemotactic Factor (ECF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA025Mu CLIA Kit for Eosinophil Chemotactic Factor (ECF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA025Ra01 Recombinant Eosinophil Chemotactic Factor (ECF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA025Ra01 Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
MAA025Ra21 Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
Assay Kits SEA025Ra ELISA Kit for Eosinophil Chemotactic Factor (ECF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA025Ra CLIA Kit for Eosinophil Chemotactic Factor (ECF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA025Gu01 Recombinant Eosinophil Chemotactic Factor (ECF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA025Gu01 Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
MAA025Gu21 Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
Assay Kits SEA025Gu ELISA Kit for Eosinophil Chemotactic Factor (ECF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA025Gu CLIA Kit for Eosinophil Chemotactic Factor (ECF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA025Si01 Recombinant Eosinophil Chemotactic Factor (ECF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA025Si01 Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
MAA025Si21 Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
Assay Kits SEA025Si ELISA Kit for Eosinophil Chemotactic Factor (ECF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA025Si CLIA Kit for Eosinophil Chemotactic Factor (ECF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA025Bo01 Recombinant Eosinophil Chemotactic Factor (ECF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA025Bo01 Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
MAA025Bo21 Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
Assay Kits SEA025Bo ELISA Kit for Eosinophil Chemotactic Factor (ECF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA025Bo CLIA Kit for Eosinophil Chemotactic Factor (ECF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA025Eq01 Recombinant Eosinophil Chemotactic Factor (ECF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA025Eq01 Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
MAA025Eq21 Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) WB; IHC; ICC; IP.
Assay Kits SEA025Eq ELISA Kit for Eosinophil Chemotactic Factor (ECF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA025Eq CLIA Kit for Eosinophil Chemotactic Factor (ECF) Chemiluminescent immunoassay for Antigen Detection.
  1. "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia."Nat. Med. 2:449-456(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils."J. Clin. Invest. 97:604-612(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3."J. Biol. Chem. 271:7725-7730(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants."Biochem. Biophys. Res. Commun. 225:1045-1051(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine."Genomics 41:471-476(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene."Biochem. Biophys. Res. Commun. 237:537-542(1997) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts."Eur. J. Biochem. 253:114-122(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation."J. Biol. Chem. 273:22471-22479(1998) [PubMed] [Europe PMC] [Abstract]