Protein C Receptor, Endothelial (PROCR)

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CD201; CCCA ;CCD41; BA42O4.2; EPCR; Endothelial Protein C Receptor; Cell Cycle, Centrosome-Associated Protein; Activated Protein C Receptor

Protein C Receptor, Endothelial (PROCR)

The endothelial cell protein C receptor (EPCR) functions as an important regulator of the protein C anticoagulant pathway by binding protein C and enhancing activation by the thrombin-thrombomodulin complex. EPCR binds to both protein C and activated protein C (APC) with high affinity.

A soluble form of EPCR (sEPCR) has recently been detected in normal rat plasma and has been shown to bind protein C and APC with an affinity similar to that of intact membrane-bound EPCR. In healthy individuals, sEPCR circulates at a concentration of 2.5 nM, a level that can increase up to 5-fold in patients with sepsis or systemic lupus erythematosus. In contrast to membrane-bound EPCR, sEPCR inhibits protein C activation over large vessel endothelium in culture.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA022Hu01 Recombinant Protein C Receptor, Endothelial (PROCR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA022Hu01 Polyclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; ICC; IHC-P; IHC-F; ELISA.
MAA022Hu22 Monoclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; IHC; ICC; IP.
LAA022Hu71 Biotin-Linked Polyclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; IHC; ICC.
Assay Kits SEA022Hu ELISA Kit for Protein C Receptor, Endothelial (PROCR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA022Mu01 Recombinant Protein C Receptor, Endothelial (PROCR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA022Mu02 Recombinant Protein C Receptor, Endothelial (PROCR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA022Mu01 Polyclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; IHC; ICC; IP.
LAA022Mu71 Biotin-Linked Polyclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; IHC; ICC.
PAA022Mu02 Polyclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; IHC; ICC; IP.
Assay Kits SEA022Mu ELISA Kit for Protein C Receptor, Endothelial (PROCR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA022Ra01 Recombinant Protein C Receptor, Endothelial (PROCR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA022Ra01 Polyclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; IHC; ICC; IP.
LAA022Ra71 Biotin-Linked Polyclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; IHC; ICC.
MAA022Ra21 Monoclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; IHC; ICC; IP.
Assay Kits SEA022Ra ELISA Kit for Protein C Receptor, Endothelial (PROCR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA022Po01 Recombinant Protein C Receptor, Endothelial (PROCR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA022Po01 Polyclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein C Receptor, Endothelial (PROCR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein C Receptor, Endothelial (PROCR) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA022Bo01 Recombinant Protein C Receptor, Endothelial (PROCR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA022Bo01 Polyclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein C Receptor, Endothelial (PROCR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein C Receptor, Endothelial (PROCR) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein C Receptor, Endothelial (PROCR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein C Receptor, Endothelial (PROCR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein C Receptor, Endothelial (PROCR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein C Receptor, Endothelial (PROCR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein C Receptor, Endothelial (PROCR) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA022Ga01 Recombinant Protein C Receptor, Endothelial (PROCR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA022Ga01 Polyclonal Antibody to Protein C Receptor, Endothelial (PROCR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein C Receptor, Endothelial (PROCR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein C Receptor, Endothelial (PROCR) ELISA Kit Customized Service Offer
  1. "Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor."J. Biol. Chem. 269:26486-26491(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains."Blood 94:632-641(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Organization and chromosomal localization of the human endothelial protein C receptor gene."Gene 238:367-373(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Metalloproteolytic release of endothelial cell protein C receptor."J. Biol. Chem. 275:6038-6044(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The crystal structure of the endothelial protein C receptor and a bound phospholipid."J. Biol. Chem. 277:24851-24854(2002) [PubMed] [Europe PMC] [Abstract]