Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3)

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CD33; Gp67; p67; Myeloid cell surface antigen CD33

Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3)

CD33 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

The myeloid antigens CD13 and CD33, which can be recognized by the monoclonal antibodies My7 and My9, respectively, are expressed by human monocytes, promyelocytes, myeloid blasts, some acute undifferentiated leukemias, and occasionally by acute lymphoblastic leukemias. By Southern blot analysis of DNA from human-hamster hybrid cells, Peiper et al. (1987) assigned CD33 to human chromosome 19. Monoclonal antibodies of the CD33 cluster group recognize a 67-kD protein, designated p67. Peiper et al. (1988) sublocalized the CD33 gene to 19q13.3 by in situ hybridization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA020Mu01 Recombinant Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA020Mu02 Recombinant Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA020Mu01 Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) WB; IHC; ICC; IP.
PAA020Mu02 Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) WB; IHC; ICC; IP.
Assay Kits SEA020Mu ELISA Kit for Sialic Acid Binding Ig Like Lectin 3 (SIGLEC3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells."J. Immunol. 141:2797-2800(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes."Gene 286:259-270(2002) [PubMed] [Europe PMC] [Abstract]
  3. "A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing."J. Leukoc. Biol. 79:46-58(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules."Blood 85:2005-2012(1995) [PubMed] [Europe PMC] [Abstract]
  8. "The sialoadhesin CD33 is a myeloid-specific inhibitory receptor."Eur. J. Immunol. 29:3440-3449(1999) [PubMed] [Europe PMC] [Abstract]
  9. "The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2."J. Biol. Chem. 274:11505-11512(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells."Proc. Natl. Acad. Sci. U.S.A. 98:5764-5769(2001) [PubMed] [Europe PMC] [Abstract]