Bone Morphogenetic Protein 4 (BMP4)

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BMP2B; BMP2-B; BMP2B1; ZYME; DVR4; Bone morphogenetic protein 2B

Bone Morphogenetic Protein 4 (BMP4)

BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5 untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA014Hu01 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA014Hu02 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
APA014Hu02 Active Bone Morphogenetic Protein 4 (BMP4) Cell culture; Activity Assays.
Antibodies PAA014Hu01 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
MAA014Hu22 Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
LAA014Hu71 Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC.
LAA014Hu81 FITC-Linked Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IF.
PAA014Hu02 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
Assay Kits SCA014Hu CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) Chemiluminescent immunoassay for Antigen Detection.
SEA014Mi ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA014Mu01 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA014Mu02 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA014Mu01 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
PAA014Mu02 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
Assay Kits SCA014Mu CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) Chemiluminescent immunoassay for Antigen Detection.
SEA014Mi ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA014Ra01 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA014Ra02 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA014Ra01 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
PAA014Ra02 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
LAA014Ra71 Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC.
Assay Kits SCA014Ra CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) Chemiluminescent immunoassay for Antigen Detection.
SEA014Mi ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA014Rb01 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA014Rb02 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA014Rb03 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA014Rb53 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
PAA014Rb51 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
PAA014Rb52 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
LAA014Rb71 Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC.
Assay Kits SEA014Rb ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA014Rb CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA014Ca01 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA014Ca01 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
MAA014Ca21 Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
Assay Kits SEA014Ca ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA014Ca CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA014Po01 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA014Po02 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA014Po01 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
LAA014Po81 FITC-Linked Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IF.
LAA014Po71 Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC.
PAA014Po02 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
Assay Kits SEA014Po ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA014Po CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA014Bo01 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA014Bo01 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
LAA014Bo71 Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC.
MAA014Bo21 Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
Assay Kits SEA014Bo ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA014Bo CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA014Cp01 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA014Cp01 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
MAA014Cp21 Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
Assay Kits SEA014Cp ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA014Cp CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA014Ga01 Recombinant Bone Morphogenetic Protein 4 (BMP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA014Ga01 Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
LAA014Ga71 Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC.
MAA014Ga21 Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) WB; IHC; ICC; IP.
Assay Kits SEA014Ga ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA014Ga CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) Chemiluminescent immunoassay for Antigen Detection.
  1. "Novel regulators of bone formation: molecular clones and activities."Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation."Calcif. Tissue Int. 63:221-229(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library."DNA Seq. 5:273-275(1995) [PubMed] [Europe PMC] [Abstract]
  5. "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney."Biochem. Biophys. Res. Commun. 316:490-500(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs)."Eur. J. Hum. Genet. 10:753-756(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways." Am. J. Hum. Genet. 82d:304-319(2008) [PubMed] [Europe PMC] [Abstract]
  8. "SIX2 and BMP4 mutations associate with anomalous kidney development."J. Am. Soc. Nephrol. 19:891-903(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip." Am. J. Hum. Genet. 84:406-411(2009) [PubMed] [Europe PMC] [Abstract]