Connective Tissue Growth Factor (CTGF)

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CCN2; HCS24; IGFBP8; NOV2; Insulin-Like Growth Factor-Binding Protein 8; Hypertrophic Chondrocyte-Specific Protein 24; CCN Family Member 2

Connective Tissue Growth Factor (CTGF)
CTGF (connective tissue growth factor) is a cysteine-rich, matrix-associated, heparin-binding protein. In vitro, CTGF mirrors some of the effects of TGF beta on skin fibroblasts, such as stimulation of extracellular matrix production, chemotaxis, proliferation and integrin expression. CTGF can promote endothelial cell growth, migration, adhesion and survival and is thus implicated in endothelial cell function and angiogenesis.
CTGF binds to perlecan, a proteoglycan which has been localised in synovium, cartilage and numerous other tissues.CTGF has been implicated in extracellular matrix remodelling in wound healing, scleroderma and other fibrotic processes, as it is capable of upregulating both matrix metalloproteinases and their inhibitors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA010Hu01 Recombinant Connective Tissue Growth Factor (CTGF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA010Hu02 Recombinant Connective Tissue Growth Factor (CTGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA010Hu01 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
MAA010Hu22 Monoclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
PAA010Hu02 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
LAA010Hu82 FITC-Linked Monoclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IF.
LAA010Hu72 Biotin-Linked Monoclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC.
LAA010Hu71 Biotin-Linked Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC.
LAA010Hu81 FITC-Linked Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IF.
MAA010Hu21 Monoclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
MAA010Hu28 Monoclonal Antibody to Connective Tissue Growth Factor (CTGF) IHC; ICC; IP.
Assay Kits SEA010Hu ELISA Kit for Connective Tissue Growth Factor (CTGF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA010Hu CLIA Kit for Connective Tissue Growth Factor (CTGF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA010Mu01 Recombinant Connective Tissue Growth Factor (CTGF) Positive Control; Immunogen; SDS-PAGE; WB.
RPA010Mu02 Recombinant Connective Tissue Growth Factor (CTGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA010Mu01 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
LAA010Mu71 Biotin-Linked Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC.
LAA010Mu81 FITC-Linked Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IF.
PAA010Mu02 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
Assay Kits SEA010Mu ELISA Kit for Connective Tissue Growth Factor (CTGF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA010Mu CLIA Kit for Connective Tissue Growth Factor (CTGF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA010Ra01 Recombinant Connective Tissue Growth Factor (CTGF) Positive Control; Immunogen; SDS-PAGE; WB.
APA010Ra01 Active Connective Tissue Growth Factor (CTGF) Cell culture; Activity Assays.
Antibodies PAA010Ra01 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
LAA010Ra71 Biotin-Linked Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC.
LAA010Ra81 FITC-Linked Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IF.
MAA010Ra21 Monoclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
LAA010Ra72 Biotin-Linked Monoclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC.
Assay Kits SEA010Ra ELISA Kit for Connective Tissue Growth Factor (CTGF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA010Ra CLIA Kit for Connective Tissue Growth Factor (CTGF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA010Rb01 Recombinant Connective Tissue Growth Factor (CTGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA010Rb51 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
MAA010Rb21 Monoclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
LAA010Rb71 Biotin-Linked Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC.
Assay Kits SEA010Rb ELISA Kit for Connective Tissue Growth Factor (CTGF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA010Rb CLIA Kit for Connective Tissue Growth Factor (CTGF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA010Po01 Recombinant Connective Tissue Growth Factor (CTGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA010Po01 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
MAA010Po21 Monoclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
LAA010Po71 Biotin-Linked Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC.
Assay Kits SEA010Po ELISA Kit for Connective Tissue Growth Factor (CTGF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA010Po CLIA Kit for Connective Tissue Growth Factor (CTGF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA010Bo01 Recombinant Connective Tissue Growth Factor (CTGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA010Bo01 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Connective Tissue Growth Factor (CTGF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connective Tissue Growth Factor (CTGF) ELISA Kit Customized Service Offer

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA010Cp01 Recombinant Connective Tissue Growth Factor (CTGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA010Cp01 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Connective Tissue Growth Factor (CTGF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connective Tissue Growth Factor (CTGF) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA010Ov01 Recombinant Connective Tissue Growth Factor (CTGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA010Ov01 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Connective Tissue Growth Factor (CTGF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connective Tissue Growth Factor (CTGF) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA010Ga01 Recombinant Connective Tissue Growth Factor (CTGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA010Ga01 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Connective Tissue Growth Factor (CTGF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connective Tissue Growth Factor (CTGF) ELISA Kit Customized Service Offer
  1. "Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10."J. Cell Biol. 114:1285-1294(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Connective tissue growth factor."J. Dermatol. 19:642-643(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Human connective tissue growth factor is expressed in advanced atherosclerotic lesions."Circulation 95:831-839(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Differential expression of novH and CTGF in human glioma cell lines."Clin. Mol. Pathol. 49:91-97(1996)
  6. "Identification of human CCN2 (connective tissue growth factor) promoter polymorphisms."J. Clin. Pathol. 54:192-196(2001)
  7. "Expression of a gene encoding a novel potential IGF binding protein in human tissues."C. R. Acad. Sci. III, Sci. Vie 313:345-351(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture."Endocrinology 141:264-273(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion."J. Endocrinol. 176:R1-R7(2003) [PubMed] [Europe PMC] [Abstract]