Amphiregulin (AREG)

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AR; CRDGF; SDGF; Colorectum Cell-Derived Growth Factor; Schwannoma-Derived Growth Factor

Amphiregulin (AREG)

Amphiregulin is a member of the EGF family of proteins. Amphiregulin is a major autocrine growth factor for cultured human keratinocytes and probably plays a role in the aberrant keratinocyte growth of hyperproliferative disorders.The protein encoded by this gene is a member of the epidermal growth factor family.

It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.Amphiregulin, also known as AREG.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA006Hu01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
APA006Hu01 Active Amphiregulin (AREG) Cell culture; Activity Assays.
Antibodies PAA006Hu01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
MAA006Hu22 Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
MAA006Hu24 Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
MAA006Hu26 Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
LAA006Hu76 Biotin-Linked Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC.
Assay Kits SEA006Hu ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA006Hu CLIA Kit for Amphiregulin (AREG) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA006Mu01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
RPA006Mu02 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA006Mu01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
PAA006Mu02 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
Assay Kits SEA006Mu ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA006Mu CLIA Kit for Amphiregulin (AREG) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA006Ra01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA006Ra01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
MAA006Ra21 Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
Assay Kits SEA006Ra ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA006Ra CLIA Kit for Amphiregulin (AREG) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA006Rb01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA006Rb51 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Amphiregulin (AREG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amphiregulin (AREG) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA006Po01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA006Po01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Amphiregulin (AREG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amphiregulin (AREG) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA006Bo01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA006Bo01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
MAA006Bo21 Monoclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
Assay Kits SEA006Bo ELISA Kit for Amphiregulin (AREG) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA006Bo CLIA Kit for Amphiregulin (AREG) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA006Eq01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA006Eq01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Amphiregulin (AREG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amphiregulin (AREG) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA006Ga01 Recombinant Amphiregulin (AREG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA006Ga01 Polyclonal Antibody to Amphiregulin (AREG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Amphiregulin (AREG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amphiregulin (AREG) ELISA Kit Customized Service Offer
  1. "The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity."Mol. Cell. Biol. 10:1969-1981(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and function of human amphiregulin: a member of the epidermal growth factor family."Science 243:1074-1076(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7."Proc. Natl. Acad. Sci. U.S.A. 85:6528-6532(1988) [PubMed] [Europe PMC] [Abstract]
  5. "A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin."Mol. Cell. Biol. 11:2547-2557(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family."Growth Factors 7:195-205(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Clarification of the C-terminal proteolytic processing site of human Amphiregulin."FEBS Lett. 586:3500-3502(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells."J. Biol. Chem. 268:2924-2931(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells."J. Cell Sci. 120:2454-2466(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the EGF-like domain from human amphiregulin."Submitted (JAN-2009) to the PDB data bank