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Angiotensin I Converting Enzyme (ACE)

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CD143; ACE1; DCP1; ACEI; ACE-I; Kininase II; Angiotensin-Converting Enzyme; Peptidyl-Dipeptidase A; Dipeptidyl Carboxypeptidase 1; Angiotensin-converting enzyme, soluble form

Angiotensin I Converting Enzyme (ACE)
CCC A004
HGNC 2707
MGI 87874
PubMed 10587334
RGD 2493
UniProt P12821
Wiki ACE

Angiotensin I-converting enzyme (ACE, EC 3.4.15.1), an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II. ACE Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. The testis-specific isoforn is expressed in spermatocytes, adult testis. ACE can Convert angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA004Hu01 Recombinant Angiotensin I Converting Enzyme (ACE) Positive Control; Immunogen; SDS-PAGE; WB.
RPA004Hu02 Recombinant Angiotensin I Converting Enzyme (ACE) Positive Control; Immunogen; SDS-PAGE; WB.
APA004Hu02 Active Angiotensin I Converting Enzyme (ACE) Cell culture; Activity Assays.
Antibodies PAA004Hu01 Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC
MAA004Hu22 Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
LAA004Hu81 FITC-Linked Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IF.
LAA004Hu71 Biotin-Linked Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC.
PAA004Hu02 Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; ICC; IHC-P; IHC-F; ELISA.
MAA004Hu21 Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
Assay Kits SEA004Hu ELISA Kit for Angiotensin I Converting Enzyme (ACE) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA004Hu CLIA Kit for Angiotensin I Converting Enzyme (ACE) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA004Mu01 Recombinant Angiotensin I Converting Enzyme (ACE) Positive Control; Immunogen; SDS-PAGE; WB.
RPA004Mu02 Recombinant Angiotensin I Converting Enzyme (ACE) Positive Control; Immunogen; SDS-PAGE; WB.
RPA004Mu03 Recombinant Angiotensin I Converting Enzyme (ACE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA004Mu01 Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
LAA004Mu71 Biotin-Linked Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC.
PAA004Mu02 Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
PAA004Mu03 Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
Assay Kits SEA004Mu ELISA Kit for Angiotensin I Converting Enzyme (ACE) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA004Mu CLIA Kit for Angiotensin I Converting Enzyme (ACE) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA004Ra01 Recombinant Angiotensin I Converting Enzyme (ACE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA004Ra01 Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
MAA004Ra21 Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
Assay Kits SEA004Ra ELISA Kit for Angiotensin I Converting Enzyme (ACE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA004Rb01 Recombinant Angiotensin I Converting Enzyme (ACE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA004Rb51 Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
MAA004Rb21 Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
Assay Kits SEA004Rb ELISA Kit for Angiotensin I Converting Enzyme (ACE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA004Po01 Recombinant Angiotensin I Converting Enzyme (ACE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA004Po01 Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
LAA004Po81 FITC-Linked Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IF.
LAA004Po71 Biotin-Linked Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC.
MAA004Po21 Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
Assay Kits SEA004Po ELISA Kit for Angiotensin I Converting Enzyme (ACE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA004Bo01 Recombinant Angiotensin I Converting Enzyme (ACE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA004Bo01 Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
MAA004Bo21 Monoclonal Antibody to Angiotensin I Converting Enzyme (ACE) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Angiotensin I Converting Enzyme (ACE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Angiotensin I Converting Enzyme (ACE) ELISA Kit Customized Service Offer
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  12. "Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites."Biochem. J. 347:711-718(2000) [PubMed] [Europe PMC] [Abstract]
  13. "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9."Circ. Res. 87:E1-E9(2000) [PubMed] [Europe PMC] [Abstract]
  14. "A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase."J. Biol. Chem. 275:33238-33243(2000) [PubMed] [Europe PMC] [Abstract]
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  18. "Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme."Biochem. J. 371:437-442(2003) [PubMed] [Europe PMC] [Abstract]
  19. "ACE2 gene expression is up-regulated in the human failing heart."BMC Med. 2:19-19(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Myocardial infarction increases ACE2 expression in rat and humans."Eur. Heart J. 26:369-375(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of the human angiotensin-converting enzyme-lisinopril complex."Nature 421:551-554(2003) [PubMed] [Europe PMC] [Abstract]
  25. "Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme."Biochemistry 43:8718-8724(2004) [PubMed] [Europe PMC] [Abstract]
  26. "Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design."J. Mol. Biol. 357:964-974(2006) [PubMed] [Europe PMC] [Abstract]
  27. "The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM."Clin. Nephrol. 51:133-140(1999) [PubMed] [Europe PMC] [Abstract]
  28. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
  29. "Point mutation in the stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-converting enzyme but no cardiovascular disease."Circulation 104:1236-1240(2001) [PubMed] [Europe PMC] [Abstract]
  30. "Hereditary elevation of angiotensin converting enzyme suggesting neurosarcoidosis."Neurology 61:1819-1820(2003) [PubMed] [Europe PMC] [Abstract]
  31. "Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls."Arch. Neurol. 61:1652-1661(2004) [PubMed] [Europe PMC] [Abstract]
  32. "DD genotype of ACE gene is a risk factor for intracerebral hemorrhage."Neurology 63:359-361(2004) [PubMed] [Europe PMC] [Abstract]
  33. "Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis."Nat. Genet. 37:964-968(2005) [PubMed] [Europe PMC] [Abstract]