Activin A (ACVA)

Activin A, a cytokine member of the transforming growth factor-beta superfamily, is expressed locally by the mesenchymal component of the hemopoietic microenvironment. Its expression is regulated on the mRNA level by different cytokines, and the biological activity of the protein is tightly controlled by several inhibitory molecules. Activin A affects hemopoietic cells of various lineages, as evidenced by in vitro studies of leukemia and lymphoma cell lines, which were used to elucidate the mechanism of its action. In the B-cell lineage, activin A is a cell cycle inhibitor, a mediator of apoptosis, and a cytokine antagonist. Limited information is available on the effects of activin A on normal hemopoietic cells. Recent studies suggest that it might be a negative regulator of normal B lymphopoiesis. Whereas the functions of activin A in vitro are well established, further research tools are needed to elucidate its role within specific hemopoietic microenvironments in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA001Hu01 Recombinant Activin A (ACVA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA001Hu01 Polyclonal Antibody to Activin A (ACVA) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits SCA001Hu CLIA Kit for Activin A (ACVA) Chemiluminescent immunoassay for Antigen Detection.
CEA001Hu ELISA Kit for Activin A (ACVA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Activin A (ACVA) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activin A (ACVA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activin A (ACVA) Polyclonal Antibody Customized Service Offer
Assay Kits CEA001Mu ELISA Kit for Activin A (ACVA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Activin A (ACVA) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activin A (ACVA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activin A (ACVA) Polyclonal Antibody Customized Service Offer
Assay Kits CEA001Ra ELISA Kit for Activin A (ACVA) Enzyme-linked immunosorbent assay for Antigen Detection.